Drug interactions
Propranolol + Stiripentol
Severity: Moderate
Propranolol and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes and may induce others, so it can change propranolol exposure unpredictably. Propranolol is partly cleared via CYP1A2 and CYP2D6, so beta-blocking effects such as bradycardia and hypotension may become stronger or weaker.
What this interaction means in plain words
Propranolol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propranolol belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP1A2 (and other CYP) activity, altering the hepatic metabolism of propranolol.
What to do
Monitor heart rate and blood pressure when starting or stopping stiripentol in a patient on propranolol. Adjust the propranolol dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Propranolol with Stiripentol?
MediHelp rates the interaction as moderate. Propranolol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes and may induce others, so it can change propranolol exposure unpredictably. Propranolol is partly cleared via CYP1A2 and CYP2D6, so beta-blocking effects such as bradycardia and hypotension may become stronger or weaker.
How serious is the interaction between Propranolol and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping stiripentol in a patient on propranolol. Adjust the propranolol dose according to clinical response.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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