Drug interactions
Propranolol + Tiotropium-olodaterol
Severity: Major
Propranolol and Tiotropium-olodaterol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol is a non-selective beta-blocker that antagonizes olodaterol and can cause severe bronchospasm in patients with COPD or asthma. Bronchodilator efficacy may be lost and respiratory status may deteriorate.
What this interaction means in plain words
Propranolol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Propranolol belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Competitive blockade of beta2 receptors by a non-selective beta-blocker opposes olodaterol bronchodilation.
What to do
Avoid propranolol in patients with obstructive airway disease. If a beta-blocker is essential, choose a cardioselective agent at low dose and monitor respiratory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tiotropium-olodaterol
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Propranolol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propranolol is a non-selective beta-blocker that antagonizes olodaterol and can cause severe bronchospasm in patients with COPD or asthma. Bronchodilator efficacy may be lost and respiratory status may deteriorate.
How serious is the interaction between Propranolol and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid propranolol in patients with obstructive airway disease. If a beta-blocker is essential, choose a cardioselective agent at low dose and monitor respiratory function.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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