Drug interactions
Propylhexedrine + Pseudoephedrine
Severity: Moderate
Propylhexedrine and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sympathomimetic decongestants, so combining them adds adrenergic stimulation. This can cause hypertension, tachycardia, palpitations, tremor and insomnia, especially in people with cardiovascular disease.
What this interaction means in plain words
Propylhexedrine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propylhexedrine belongs to Respiratory; Pseudoephedrine belongs to Respiratory.
Why it happens
Additive pharmacodynamic sympathomimetic (adrenergic agonist) activity.
What to do
Avoid using both decongestants together; choose one agent. Monitor blood pressure and heart rate if concurrent use cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Propylhexedrine and Pseudoephedrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Propylhexedrine with Pseudoephedrine?
MediHelp rates the interaction as moderate. Propylhexedrine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sympathomimetic decongestants, so combining them adds adrenergic stimulation. This can cause hypertension, tachycardia, palpitations, tremor and insomnia, especially in people with cardiovascular disease.
How serious is the interaction between Propylhexedrine and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both decongestants together; choose one agent. Monitor blood pressure and heart rate if concurrent use cannot be avoided.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
