Drug interactions
Propylhexedrine + Salbutamol
Severity: Moderate
Propylhexedrine and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is a sympathomimetic decongestant, and combining it with salbutamol can add to adrenergic stimulation. This may cause tachycardia, palpitations, tremor and raised blood pressure, which matter most in patients with cardiovascular disease.
What this interaction means in plain words
Propylhexedrine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propylhexedrine belongs to Respiratory; Salbutamol belongs to Respiratory.
Why it happens
Additive sympathomimetic effects through direct beta-2 agonism and indirect norepinephrine release.
What to do
Monitor heart rate and blood pressure and avoid routine concurrent use in patients with hypertension or arrhythmia. Advise patients to report palpitations or chest pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Propylhexedrine with Salbutamol?
MediHelp rates the interaction as moderate. Propylhexedrine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylhexedrine is a sympathomimetic decongestant, and combining it with salbutamol can add to adrenergic stimulation. This may cause tachycardia, palpitations, tremor and raised blood pressure, which matter most in patients with cardiovascular disease.
How serious is the interaction between Propylhexedrine and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and avoid routine concurrent use in patients with hypertension or arrhythmia. Advise patients to report palpitations or chest pain.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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