Drug interactions
Propylthiouracil + Tiratricol
Severity: Moderate
Propylthiouracil and Tiratricol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylthiouracil reduces thyroid hormone synthesis and blocks T4 to T3 conversion, which opposes tiratricol and confounds thyroid monitoring. The combination makes dosing of both unpredictable.
What this interaction means in plain words
Propylthiouracil and Tiratricol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propylthiouracil belongs to Endocrine; Tiratricol belongs to Endocrine.
Why it happens
Pharmacodynamic opposition: antithyroid inhibition of hormone synthesis and conversion versus exogenous thyromimetic.
What to do
Avoid unless directed by an endocrinologist. If combined, monitor thyroid function and clinical status closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiratricol
- Levothyroxine + Tiratricol Major
- Calcium + Tiratricol Moderate
- Carbamazepine + Tiratricol Moderate
- Carbimazole + Tiratricol Moderate
- Charcoal + Tiratricol Moderate
- Chloroquine + Tiratricol Moderate
Other interactions of Propylthiouracil
Frequently asked questions
Can I take Propylthiouracil with Tiratricol?
MediHelp rates the interaction as moderate. Propylthiouracil and Tiratricol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylthiouracil reduces thyroid hormone synthesis and blocks T4 to T3 conversion, which opposes tiratricol and confounds thyroid monitoring. The combination makes dosing of both unpredictable.
How serious is the interaction between Propylthiouracil and Tiratricol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless directed by an endocrinologist. If combined, monitor thyroid function and clinical status closely.
What other medicines interact with Tiratricol?
MediHelp also lists interactions of Tiratricol with, for example, Levothyroxine, Calcium, Carbamazepine. The full list is on the Tiratricol page.
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