Drug interactions
Protriptyline + Vilazodone
Severity: Major
Protriptyline and Vilazodone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents raise synaptic serotonin, so concurrent use increases the risk of serotonin syndrome. Protriptyline is a tricyclic and may also have its levels affected by serotonergic antidepressants.
What this interaction means in plain words
Protriptyline and Vilazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonin reuptake inhibition.
What to do
Avoid unless clearly necessary. If used, start low and monitor for serotonin syndrome and anticholinergic or cardiac effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Protriptyline with Vilazodone?
MediHelp rates the interaction as major. Protriptyline and Vilazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents raise synaptic serotonin, so concurrent use increases the risk of serotonin syndrome. Protriptyline is a tricyclic and may also have its levels affected by serotonergic antidepressants.
How serious is the interaction between Protriptyline and Vilazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clearly necessary. If used, start low and monitor for serotonin syndrome and anticholinergic or cardiac effects.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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