Drug interactions
Quetiapine + Ribociclib
Severity: Major
Quetiapine and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib causes dose-dependent QT prolongation and quetiapine adds to this effect. Ribociclib also inhibits CYP3A4, which may raise quetiapine levels.
What this interaction means in plain words
Quetiapine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quetiapine belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by ribociclib reducing quetiapine clearance.
What to do
Avoid if possible; otherwise perform ECG at baseline and during therapy and monitor electrolytes. Consider reducing the quetiapine dose and be ready to interrupt ribociclib for QTc prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Quetiapine with Ribociclib?
MediHelp rates the interaction as major. Quetiapine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib causes dose-dependent QT prolongation and quetiapine adds to this effect. Ribociclib also inhibits CYP3A4, which may raise quetiapine levels.
How serious is the interaction between Quetiapine and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise perform ECG at baseline and during therapy and monitor electrolytes. Consider reducing the quetiapine dose and be ready to interrupt ribociclib for QTc prolongation.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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