Drug interactions
Quetiapine + Selinexor
Severity: Moderate
Quetiapine and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and fatigue, and quetiapine can add to sedation and dizziness. Together they may increase the risk of falls and cognitive impairment.
What this interaction means in plain words
Quetiapine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive CNS adverse effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation, and counsel on fall precautions. Reduce the quetiapine dose if neurological symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Quetiapine with Selinexor?
MediHelp rates the interaction as moderate. Quetiapine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and fatigue, and quetiapine can add to sedation and dizziness. Together they may increase the risk of falls and cognitive impairment.
How serious is the interaction between Quetiapine and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, and counsel on fall precautions. Reduce the quetiapine dose if neurological symptoms emerge.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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