Drug interactions
Quetiapine + Solifenacin
Severity: Moderate
Quetiapine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine can prolong the QT interval and has antimuscarinic metabolite activity, and solifenacin adds to both effects. This raises the risk of arrhythmia and of anticholinergic effects such as sedation, confusion and constipation.
What this interaction means in plain words
Quetiapine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation and additive antimuscarinic activity.
What to do
Monitor the ECG in patients with other QT risk factors and watch for anticholinergic effects in older adults. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Solifenacin?
MediHelp rates the interaction as moderate. Quetiapine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine can prolong the QT interval and has antimuscarinic metabolite activity, and solifenacin adds to both effects. This raises the risk of arrhythmia and of anticholinergic effects such as sedation, confusion and constipation.
How serious is the interaction between Quetiapine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG in patients with other QT risk factors and watch for anticholinergic effects in older adults. Use the lowest effective doses.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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