Drug interactions
Quetiapine + Tacrolimus
Severity: Moderate
Quetiapine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT prolongation, so the combination may increase the risk of ventricular arrhythmias. Tacrolimus can also cause hypomagnesemia and hyperkalemia, which further affect the risk.
What this interaction means in plain words
Quetiapine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation, with tacrolimus-related electrolyte disturbances as a further contributor.
What to do
Obtain a baseline ECG and repeat it after changes in dose or therapy. Monitor magnesium, potassium and calcium and correct abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Quetiapine with Tacrolimus?
MediHelp rates the interaction as moderate. Quetiapine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QT prolongation, so the combination may increase the risk of ventricular arrhythmias. Tacrolimus can also cause hypomagnesemia and hyperkalemia, which further affect the risk.
How serious is the interaction between Quetiapine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after changes in dose or therapy. Monitor magnesium, potassium and calcium and correct abnormalities.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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