Drug interactions
Quetiapine + Temazepam
Severity: Moderate
Quetiapine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine and temazepam each cause sedation, so combined use can produce greater drowsiness, impaired coordination and, in vulnerable patients, respiratory depression. Falls are a particular concern in older adults.
What this interaction means in plain words
Quetiapine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via H1 and alpha-1 blockade by quetiapine and GABA-A potentiation by temazepam.
What to do
Use the lowest effective doses and counsel patients on driving and fall risk. Monitor older patients for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Quetiapine with Temazepam?
MediHelp rates the interaction as moderate. Quetiapine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine and temazepam each cause sedation, so combined use can produce greater drowsiness, impaired coordination and, in vulnerable patients, respiratory depression. Falls are a particular concern in older adults.
How serious is the interaction between Quetiapine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients on driving and fall risk. Monitor older patients for oversedation.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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