Drug interactions
Quetiapine + Vorinostat
Severity: Moderate
Quetiapine and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, and quetiapine can also prolong the QT interval. Using both may increase the risk of torsades de pointes, especially when electrolyte disturbances are present, as is common in patients with cancer.
What this interaction means in plain words
Quetiapine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check baseline and periodic ECGs and correct hypokalemia and hypomagnesemia before and during therapy. Consider an alternative antipsychotic if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Quetiapine with Vorinostat?
MediHelp rates the interaction as moderate. Quetiapine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation, and quetiapine can also prolong the QT interval. Using both may increase the risk of torsades de pointes, especially when electrolyte disturbances are present, as is common in patients with cancer.
How serious is the interaction between Quetiapine and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and periodic ECGs and correct hypokalemia and hypomagnesemia before and during therapy. Consider an alternative antipsychotic if the QTc becomes prolonged.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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