Drug interactions
Quetiapine + Ziconotide
Severity: Moderate
Quetiapine and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intrathecal ziconotide commonly causes dizziness, confusion, sedation and other neuropsychiatric effects, and can cause psychosis. Quetiapine adds sedation, and the cognitive effects of ziconotide may be harder to assess. The label warns of CNS depressant co-use.
What this interaction means in plain words
Quetiapine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depression; ziconotide blocks N-type calcium channels and quetiapine antagonizes histamine and other receptors.
What to do
Monitor for oversedation, confusion and mood or psychotic symptoms. Reduce the dose of one agent if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Quetiapine with Ziconotide?
MediHelp rates the interaction as moderate. Quetiapine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intrathecal ziconotide commonly causes dizziness, confusion, sedation and other neuropsychiatric effects, and can cause psychosis. Quetiapine adds sedation, and the cognitive effects of ziconotide may be harder to assess. The label warns of CNS depressant co-use.
How serious is the interaction between Quetiapine and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, confusion and mood or psychotic symptoms. Reduce the dose of one agent if impairment occurs.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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