Drug interactions
Quinidine + Ritlecitinib
Severity: Moderate
Quinidine and Ritlecitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib may inhibit CYP3A4 and could raise concentrations of CYP3A4 substrates such as quinidine. Higher quinidine exposure may increase QT prolongation and other dose-related toxicity.
What this interaction means in plain words
Quinidine and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Ritlecitinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of quinidine.
What to do
Monitor ECG/QTc and quinidine plasma concentrations, and reduce the quinidine dose if exposure or adverse effects increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Quinidine with Ritlecitinib?
MediHelp rates the interaction as moderate. Quinidine and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib may inhibit CYP3A4 and could raise concentrations of CYP3A4 substrates such as quinidine. Higher quinidine exposure may increase QT prolongation and other dose-related toxicity.
How serious is the interaction between Quinidine and Ritlecitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG/QTc and quinidine plasma concentrations, and reduce the quinidine dose if exposure or adverse effects increase.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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