Drug interactions
Quinidine + Rivaroxaban
Severity: Moderate
Quinidine and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein and weakly inhibits CYP3A4, which may increase rivaroxaban exposure. The increase is more important in renal impairment and may raise the risk of bleeding.
What this interaction means in plain words
Quinidine and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Rivaroxaban belongs to Cardiovascular.
Why it happens
Quinidine inhibits P-gp and CYP3A4, which reduces rivaroxaban clearance.
What to do
Monitor for signs of bleeding and check renal function and hemoglobin. In patients with renal impairment, use the combination only if the benefit clearly outweighs the risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Quinidine with Rivaroxaban?
MediHelp rates the interaction as moderate. Quinidine and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits P-glycoprotein and weakly inhibits CYP3A4, which may increase rivaroxaban exposure. The increase is more important in renal impairment and may raise the risk of bleeding.
How serious is the interaction between Quinidine and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check renal function and hemoglobin. In patients with renal impairment, use the combination only if the benefit clearly outweighs the risk.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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