Drug interactions
Quinidine + Sarilumab
Severity: Moderate
Quinidine and Sarilumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
IL-6 suppresses CYP450 enzymes during inflammation, and sarilumab can reverse this and restore enzyme activity. Quinidine concentrations may therefore fall after sarilumab is started, with possible loss of effect. The reverse may occur when sarilumab is stopped.
What this interaction means in plain words
Quinidine and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Sarilumab belongs to Musculoskeletal.
Why it happens
IL-6 receptor blockade normalizes suppressed CYP3A4 expression and increases quinidine metabolism.
What to do
Monitor quinidine concentrations and the ECG when sarilumab is started or stopped. Adjust the quinidine dose based on levels and response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Sarilumab
Frequently asked questions
Can I take Quinidine with Sarilumab?
MediHelp rates the interaction as moderate. Quinidine and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. IL-6 suppresses CYP450 enzymes during inflammation, and sarilumab can reverse this and restore enzyme activity. Quinidine concentrations may therefore fall after sarilumab is started, with possible loss of effect. The reverse may occur when sarilumab is stopped.
How serious is the interaction between Quinidine and Sarilumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor quinidine concentrations and the ECG when sarilumab is started or stopped. Adjust the quinidine dose based on levels and response.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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