Drug interactions
Quinidine + Saxagliptin
Severity: Moderate
Quinidine and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine can inhibit CYP3A4 and increase saxagliptin levels, along with its active metabolite exposure shifting. Increased exposure is usually modest and manageable.
What this interaction means in plain words
Quinidine and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Saxagliptin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4/5-mediated saxagliptin metabolism by quinidine.
What to do
Limit saxagliptin to 2.5 mg daily if a strong CYP3A4 inhibitor effect is expected, and monitor glucose control and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Quinidine with Saxagliptin?
MediHelp rates the interaction as moderate. Quinidine and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine can inhibit CYP3A4 and increase saxagliptin levels, along with its active metabolite exposure shifting. Increased exposure is usually modest and manageable.
How serious is the interaction between Quinidine and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg daily if a strong CYP3A4 inhibitor effect is expected, and monitor glucose control and adverse effects.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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