Drug interactions
Quinidine + Solifenacin
Severity: Major
Quinidine and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine strongly prolongs the QT interval and carries a well-known risk of torsades de pointes, and solifenacin may add to this effect. Quinidine also inhibits CYP3A4 weakly, which might modestly raise solifenacin levels.
What this interaction means in plain words
Quinidine and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinidine belongs to Anti Parasitic; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation, with possible minor CYP3A4 inhibition by quinidine.
What to do
Avoid the combination if possible; if it is necessary, obtain a baseline and follow-up ECG and keep potassium and magnesium normal. Consider an alternative to solifenacin in patients with a prolonged QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Solifenacin?
MediHelp rates the interaction as major. Quinidine and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinidine strongly prolongs the QT interval and carries a well-known risk of torsades de pointes, and solifenacin may add to this effect. Quinidine also inhibits CYP3A4 weakly, which might modestly raise solifenacin levels.
How serious is the interaction between Quinidine and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if it is necessary, obtain a baseline and follow-up ECG and keep potassium and magnesium normal. Consider an alternative to solifenacin in patients with a prolonged QTc.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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