Drug interactions
Quinidine + Sonidegib
Severity: Moderate
Quinidine and Sonidegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a CYP3A4 inhibitor and may raise sonidegib exposure. This could worsen musculoskeletal toxicity, including rhabdomyolysis.
What this interaction means in plain words
Quinidine and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Sonidegib belongs to Oncology.
Why it happens
Quinidine inhibits CYP3A4 metabolism of sonidegib.
What to do
Monitor for muscle symptoms and check creatine kinase if symptoms occur. Interrupt sonidegib if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Quinidine with Sonidegib?
MediHelp rates the interaction as moderate. Quinidine and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a CYP3A4 inhibitor and may raise sonidegib exposure. This could worsen musculoskeletal toxicity, including rhabdomyolysis.
How serious is the interaction between Quinidine and Sonidegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and check creatine kinase if symptoms occur. Interrupt sonidegib if toxicity develops.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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