Drug interactions
Quinidine + Talquetamab
Severity: Moderate
Quinidine and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release, which temporarily suppresses CYP450 enzymes and can raise concentrations of CYP substrates such as quinidine. Quinidine toxicity, including QT prolongation, may result, especially around step-up dosing and during cytokine release syndrome.
What this interaction means in plain words
Quinidine and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 reduces quinidine metabolism.
What to do
Monitor ECG and quinidine levels during talquetamab step-up dosing and for about two weeks after, and during any cytokine release syndrome. Reduce the quinidine dose if concentrations or QTc rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Quinidine with Talquetamab?
MediHelp rates the interaction as moderate. Quinidine and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release, which temporarily suppresses CYP450 enzymes and can raise concentrations of CYP substrates such as quinidine. Quinidine toxicity, including QT prolongation, may result, especially around step-up dosing and during cytokine release syndrome.
How serious is the interaction between Quinidine and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and quinidine levels during talquetamab step-up dosing and for about two weeks after, and during any cytokine release syndrome. Reduce the quinidine dose if concentrations or QTc rise.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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