Drug interactions
Quinidine + Tazemetostat
Severity: Moderate
Quinidine and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and may lower quinidine levels. Quinidine may in turn modestly raise tazemetostat exposure as a CYP3A4 substrate inhibitor, so the net effect on each drug is uncertain.
What this interaction means in plain words
Quinidine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat weakly induces CYP3A4 while quinidine weakly inhibits it, altering the exposure of both drugs.
What to do
Monitor quinidine levels, ECG and clinical response when tazemetostat is started or stopped. Watch for tazemetostat adverse effects and adjust doses according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Quinidine with Tazemetostat?
MediHelp rates the interaction as moderate. Quinidine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak CYP3A4 inducer and may lower quinidine levels. Quinidine may in turn modestly raise tazemetostat exposure as a CYP3A4 substrate inhibitor, so the net effect on each drug is uncertain.
How serious is the interaction between Quinidine and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor quinidine levels, ECG and clinical response when tazemetostat is started or stopped. Watch for tazemetostat adverse effects and adjust doses according to response.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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