Drug interactions
Quinidine + Tipranavir
Severity: Contraindicated
Quinidine and Tipranavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, boosted with ritonavir, strongly inhibits CYP3A4 and can greatly increase quinidine concentrations. This raises the risk of serious ventricular arrhythmia and is contraindicated in labeling.
What this interaction means in plain words
Quinidine and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Quinidine belongs to Anti Parasitic; Tipranavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by ritonavir-boosted tipranavir decreases quinidine metabolism.
What to do
Do not co-administer; use an alternative antiarrhythmic or antiretroviral regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Quinidine with Tipranavir?
MediHelp rates the interaction as contraindicated. Quinidine and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir, boosted with ritonavir, strongly inhibits CYP3A4 and can greatly increase quinidine concentrations. This raises the risk of serious ventricular arrhythmia and is contraindicated in labeling.
How serious is the interaction between Quinidine and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative antiarrhythmic or antiretroviral regimen.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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