Drug interactions
Quinine + Repotrectinib
Severity: Major
Quinine and Repotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib induces CYP3A4 and may lower quinine concentrations, risking antimalarial failure. Quinine may also inhibit P-glycoprotein and modestly raise repotrectinib levels.
What this interaction means in plain words
Quinine and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinine belongs to Anti Parasitic; Repotrectinib belongs to Oncology.
Why it happens
Repotrectinib induces CYP3A4 metabolism of quinine, and quinine inhibits P-gp transport of repotrectinib.
What to do
Avoid the combination and choose an alternative antimalarial. If unavoidable, monitor for loss of quinine efficacy and repotrectinib toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Quinine with Repotrectinib?
MediHelp rates the interaction as major. Quinine and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Repotrectinib induces CYP3A4 and may lower quinine concentrations, risking antimalarial failure. Quinine may also inhibit P-glycoprotein and modestly raise repotrectinib levels.
How serious is the interaction between Quinine and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antimalarial. If unavoidable, monitor for loss of quinine efficacy and repotrectinib toxicity.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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