Drug interactions
Quinine + Risperidone
Severity: Moderate
Quinine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase arrhythmia risk, particularly with other predisposing factors. Quinine may also inhibit CYP2D6, raising risperidone exposure.
What this interaction means in plain words
Quinine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinine belongs to Anti Parasitic; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with quinine inhibition of CYP2D6 metabolism of risperidone.
What to do
Obtain baseline ECG and correct electrolyte disturbances; monitor for risperidone adverse effects and ECG changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Quinine with Risperidone?
MediHelp rates the interaction as moderate. Quinine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may increase arrhythmia risk, particularly with other predisposing factors. Quinine may also inhibit CYP2D6, raising risperidone exposure.
How serious is the interaction between Quinine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and correct electrolyte disturbances; monitor for risperidone adverse effects and ECG changes.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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