Drug interactions
Quinine + Rucaparib
Severity: Minor
Quinine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak CYP3A4 inhibitor and may modestly raise quinine concentrations. This could increase quinine adverse effects including cinchonism and QT prolongation.
What this interaction means in plain words
Quinine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Quinine belongs to Anti Parasitic; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 metabolism of quinine by rucaparib.
What to do
Monitor for quinine adverse effects such as tinnitus and palpitations. Dose adjustment is usually not needed unless toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Quinine with Rucaparib?
MediHelp rates the interaction as minor. Quinine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak CYP3A4 inhibitor and may modestly raise quinine concentrations. This could increase quinine adverse effects including cinchonism and QT prolongation.
How serious is the interaction between Quinine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine adverse effects such as tinnitus and palpitations. Dose adjustment is usually not needed unless toxicity occurs.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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