Drug interactions
Quinine + Ruxolitinib
Severity: Minor
Quinine and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine is a weak CYP3A4 inhibitor and may modestly raise ruxolitinib concentrations. Higher exposure could increase cytopenias.
What this interaction means in plain words
Quinine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Quinine belongs to Anti Parasitic; Ruxolitinib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated ruxolitinib metabolism by quinine.
What to do
Monitor blood counts during co-therapy and reduce the ruxolitinib dose if cytopenias develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Quinine with Ruxolitinib?
MediHelp rates the interaction as minor. Quinine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinine is a weak CYP3A4 inhibitor and may modestly raise ruxolitinib concentrations. Higher exposure could increase cytopenias.
How serious is the interaction between Quinine and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts during co-therapy and reduce the ruxolitinib dose if cytopenias develop.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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