Drug interactions
Quinine + Sevoflurane
Severity: Moderate
Quinine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval and quinine does too, increasing arrhythmia risk during anesthesia. Quinine may also enhance neuromuscular blockade.
What this interaction means in plain words
Quinine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinine belongs to Anti Parasitic; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation; quinine has weak neuromuscular blocking activity.
What to do
Inform the anesthesia team of quinine use and monitor ECG and electrolytes perioperatively. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Quinine with Sevoflurane?
MediHelp rates the interaction as moderate. Quinine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval and quinine does too, increasing arrhythmia risk during anesthesia. Quinine may also enhance neuromuscular blockade.
How serious is the interaction between Quinine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of quinine use and monitor ECG and electrolytes perioperatively. Avoid adding other QT-prolonging drugs.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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