Drug interactions
Quinine + Sotalol
Severity: Contraindicated
Quinine and Sotalol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a class III antiarrhythmic with substantial QT-prolonging and torsadogenic potential, and quinine adds to this effect. The combination markedly raises the risk of life-threatening ventricular arrhythmia.
What this interaction means in plain words
Quinine and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Quinine belongs to Anti Parasitic; Sotalol belongs to Cardiovascular.
Why it happens
Additive QT prolongation through potassium channel blockade.
What to do
Avoid the combination; use an alternative antimalarial or antiarrhythmic. If unavoidable, use continuous ECG monitoring with electrolyte correction.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Quinine with Sotalol?
MediHelp rates the interaction as contraindicated. Quinine and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sotalol is a class III antiarrhythmic with substantial QT-prolonging and torsadogenic potential, and quinine adds to this effect. The combination markedly raises the risk of life-threatening ventricular arrhythmia.
How serious is the interaction between Quinine and Sotalol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative antimalarial or antiarrhythmic. If unavoidable, use continuous ECG monitoring with electrolyte correction.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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