Drug interactions
Quinine + Tiotropium-olodaterol
Severity: Moderate
Quinine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine can prolong the QT interval, and olodaterol may add to arrhythmia risk through hypokalemia and sympathetic stimulation. The risk is greatest with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Quinine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinine belongs to Anti Parasitic; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta2-induced hypokalemia.
What to do
Check potassium and magnesium and obtain an ECG if other QT risk factors are present. Avoid exceeding recommended olodaterol dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Quinine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Quinine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine can prolong the QT interval, and olodaterol may add to arrhythmia risk through hypokalemia and sympathetic stimulation. The risk is greatest with cardiac disease or electrolyte disturbance.
How serious is the interaction between Quinine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and obtain an ECG if other QT risk factors are present. Avoid exceeding recommended olodaterol dosing.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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