Drug interactions
Quinine + Triclabendazole
Severity: Major
Quinine and Triclabendazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole can prolong the QT interval, and quinine has the same effect. Concurrent use may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Quinine and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinine belongs to Anti Parasitic; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid concurrent use if possible, or obtain an ECG and correct electrolytes beforehand. Monitor for palpitations or syncope.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Quinine with Triclabendazole?
MediHelp rates the interaction as major. Quinine and Triclabendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triclabendazole can prolong the QT interval, and quinine has the same effect. Concurrent use may increase the risk of ventricular arrhythmia.
How serious is the interaction between Quinine and Triclabendazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible, or obtain an ECG and correct electrolytes beforehand. Monitor for palpitations or syncope.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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