Drug interactions
Quinine + Vortioxetine
Severity: Moderate
Quinine and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine inhibits CYP2D6, the main enzyme metabolizing vortioxetine, and may raise vortioxetine levels. This can increase nausea and other adverse effects.
What this interaction means in plain words
Quinine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinine belongs to Anti Parasitic; Vortioxetine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by quinine reduces vortioxetine clearance.
What to do
Monitor for adverse effects such as nausea and consider reducing the vortioxetine dose. Return to the usual dose once quinine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Quinine with Vortioxetine?
MediHelp rates the interaction as moderate. Quinine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine inhibits CYP2D6, the main enzyme metabolizing vortioxetine, and may raise vortioxetine levels. This can increase nausea and other adverse effects.
How serious is the interaction between Quinine and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects such as nausea and consider reducing the vortioxetine dose. Return to the usual dose once quinine is stopped.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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