Drug interactions
Quizartinib + Ribociclib
Severity: Major
Quizartinib and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and sudden cardiac death. Ribociclib also inhibits CYP3A4, which may increase quizartinib exposure.
What this interaction means in plain words
Quizartinib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quizartinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Additive QTc prolongation, with CYP3A4 inhibition raising quizartinib levels.
What to do
Avoid if possible; otherwise monitor ECG frequently, correct potassium and magnesium, and reduce the quizartinib dose per labeling for CYP3A inhibitors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Quizartinib with Ribociclib?
MediHelp rates the interaction as major. Quizartinib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and sudden cardiac death. Ribociclib also inhibits CYP3A4, which may increase quizartinib exposure.
How serious is the interaction between Quizartinib and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG frequently, correct potassium and magnesium, and reduce the quizartinib dose per labeling for CYP3A inhibitors.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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