Drug interactions
Quizartinib + Solifenacin
Severity: Major
Quizartinib and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib markedly prolongs the QT interval and has a boxed warning for torsades de pointes. Adding solifenacin, which can also prolong QT, increases the arrhythmia risk.
What this interaction means in plain words
Quizartinib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quizartinib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarisation (QT interval).
What to do
Avoid the combination where possible, and consider a bladder agent without QT effect. If used together, monitor ECGs frequently and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Quizartinib with Solifenacin?
MediHelp rates the interaction as major. Quizartinib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib markedly prolongs the QT interval and has a boxed warning for torsades de pointes. Adding solifenacin, which can also prolong QT, increases the arrhythmia risk.
How serious is the interaction between Quizartinib and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and consider a bladder agent without QT effect. If used together, monitor ECGs frequently and keep potassium and magnesium normal.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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