Drug interactions
Rabeprazole + Tucatinib
Severity: Minor
Rabeprazole and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabeprazole is not a meaningful CYP2C8 inhibitor, and tucatinib is a CYP3A inhibitor while rabeprazole is mainly cleared non-enzymatically. Any clinically important interaction is unlikely.
What this interaction means in plain words
Rabeprazole and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rabeprazole belongs to Gastrointestinal Tract; Tucatinib belongs to Oncology.
Why it happens
Tucatinib may weakly inhibit the minor CYP3A pathway of rabeprazole metabolism; no relevant effect on tucatinib is established.
What to do
No routine adjustment is needed; monitor for rabeprazole adverse effects only if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Rabeprazole with Tucatinib?
MediHelp rates the interaction as minor. Rabeprazole and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rabeprazole is not a meaningful CYP2C8 inhibitor, and tucatinib is a CYP3A inhibitor while rabeprazole is mainly cleared non-enzymatically. Any clinically important interaction is unlikely.
How serious is the interaction between Rabeprazole and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for rabeprazole adverse effects only if clinically indicated.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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