Drug interactions
Rabies vaccine chick embryo cell derived + Secukinumab
Severity: Moderate
Rabies vaccine chick embryo cell derived and Secukinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secukinumab blocks IL-17A, which may modestly alter immune responses to vaccination. An inactivated chick embryo cell rabies vaccine given during therapy could produce a weaker antibody response, though data with other non-live vaccines suggest responses are generally adequate. Because rabies is almost invariably fatal, protection should be confirmed.
What this interaction means in plain words
Rabies vaccine chick embryo cell derived and Secukinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
IL-17A inhibition by secukinumab may modulate the immune response to vaccine antigens, with a theoretical reduction in immunogenicity.
What to do
Do not withhold rabies vaccination, particularly for post-exposure prophylaxis; complete it according to schedule. Check neutralizing antibody titers when exposure risk persists and boost as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Rabies vaccine chick embryo cell derived with Secukinumab?
MediHelp rates the interaction as moderate. Rabies vaccine chick embryo cell derived and Secukinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secukinumab blocks IL-17A, which may modestly alter immune responses to vaccination. An inactivated chick embryo cell rabies vaccine given during therapy could produce a weaker antibody response, though data with other non-live vaccines suggest responses are generally adequate. Because rabies is almost invariably fatal, protection should be confirmed.
How serious is the interaction between Rabies vaccine chick embryo cell derived and Secukinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold rabies vaccination, particularly for post-exposure prophylaxis; complete it according to schedule. Check neutralizing antibody titers when exposure risk persists and boost as needed.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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