Drug interactions
Ramelteon + Ribociclib
Severity: Minor
Ramelteon and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor, and CYP3A4 is a secondary metabolic route for ramelteon. Exposure to ramelteon may rise modestly, increasing drowsiness or dizziness. The effect is expected to be less than with strong CYP1A2 inhibitors.
What this interaction means in plain words
Ramelteon and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ramelteon belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated ramelteon metabolism by ribociclib.
What to do
No dose adjustment is usually needed. Monitor for excess sedation and reduce or stop ramelteon if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ramelteon with Ribociclib?
MediHelp rates the interaction as minor. Ramelteon and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate-to-strong CYP3A4 inhibitor, and CYP3A4 is a secondary metabolic route for ramelteon. Exposure to ramelteon may rise modestly, increasing drowsiness or dizziness. The effect is expected to be less than with strong CYP1A2 inhibitors.
How serious is the interaction between Ramelteon and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for excess sedation and reduce or stop ramelteon if it occurs.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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