Drug interactions
Ramelteon + Ritlecitinib
Severity: Moderate
Ramelteon and Ritlecitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib inhibits CYP1A2, the main pathway for ramelteon metabolism, so ramelteon exposure may rise. This could cause more drowsiness, dizziness and other adverse effects.
What this interaction means in plain words
Ramelteon and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ramelteon belongs to Central Nervous System; Ritlecitinib belongs to Oncology.
Why it happens
Inhibition of CYP1A2-mediated metabolism of ramelteon.
What to do
Monitor for increased sedation and consider a lower ramelteon dose. Use of strong CYP1A2 inhibitors such as fluvoxamine with ramelteon is contraindicated, so reassess if effects are marked.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Ramelteon with Ritlecitinib?
MediHelp rates the interaction as moderate. Ramelteon and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib inhibits CYP1A2, the main pathway for ramelteon metabolism, so ramelteon exposure may rise. This could cause more drowsiness, dizziness and other adverse effects.
How serious is the interaction between Ramelteon and Ritlecitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and consider a lower ramelteon dose. Use of strong CYP1A2 inhibitors such as fluvoxamine with ramelteon is contraindicated, so reassess if effects are marked.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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