Drug interactions
Ramelteon + Temazepam
Severity: Moderate
Ramelteon and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking both hypnotics together may increase drowsiness, impaired coordination and next-day sedation. There is little justification for dual hypnotic therapy in most patients.
What this interaction means in plain words
Ramelteon and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ramelteon belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via melatonin receptor agonism and GABA-A enhancement.
What to do
Avoid combining unless clearly needed and use the lowest effective doses. Monitor for next-day sedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Ramelteon with Temazepam?
MediHelp rates the interaction as moderate. Ramelteon and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking both hypnotics together may increase drowsiness, impaired coordination and next-day sedation. There is little justification for dual hypnotic therapy in most patients.
How serious is the interaction between Ramelteon and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless clearly needed and use the lowest effective doses. Monitor for next-day sedation and falls.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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