Drug interactions
Ramelteon + Voriconazole
Severity: Minor
Ramelteon and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase ramelteon exposure, which could cause more daytime drowsiness and dizziness. Ramelteon is metabolized mainly by CYP1A2, with minor CYP2C9 and CYP3A4 contributions.
What this interaction means in plain words
Ramelteon and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ramelteon belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 and CYP2C9 minor metabolic pathways of ramelteon by voriconazole.
What to do
Watch for excess sedation and dizziness. Reduce the ramelteon dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ramelteon with Voriconazole?
MediHelp rates the interaction as minor. Ramelteon and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole may increase ramelteon exposure, which could cause more daytime drowsiness and dizziness. Ramelteon is metabolized mainly by CYP1A2, with minor CYP2C9 and CYP3A4 contributions.
How serious is the interaction between Ramelteon and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for excess sedation and dizziness. Reduce the ramelteon dose if these occur.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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