Drug interactions
Ramipril + Temsirolimus
Severity: Moderate
Ramipril and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus is metabolized to sirolimus, and use with an ACE inhibitor has been associated with a higher risk of angioedema. Reactions can be serious if the airway is involved.
What this interaction means in plain words
Ramipril and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ramipril belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Additive impairment of bradykinin degradation from ACE inhibition and mTOR inhibitor effects.
What to do
Educate patients to report facial or oropharyngeal swelling promptly. Discontinue ramipril and use a different antihypertensive class if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Ramipril with Temsirolimus?
MediHelp rates the interaction as moderate. Ramipril and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus is metabolized to sirolimus, and use with an ACE inhibitor has been associated with a higher risk of angioedema. Reactions can be serious if the airway is involved.
How serious is the interaction between Ramipril and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Educate patients to report facial or oropharyngeal swelling promptly. Discontinue ramipril and use a different antihypertensive class if angioedema occurs.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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