Drug interactions
Ranolazine + Rufinamide
Severity: Moderate
Ranolazine and Rufinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer and may lower ranolazine concentrations. The effect is likely modest but could weaken antianginal efficacy.
What this interaction means in plain words
Ranolazine and Rufinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Rufinamide belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by rufinamide increasing ranolazine metabolism.
What to do
Monitor angina frequency and increase ranolazine dose within the labeled maximum if response is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Ranolazine with Rufinamide?
MediHelp rates the interaction as moderate. Ranolazine and Rufinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rufinamide is a weak CYP3A4 inducer and may lower ranolazine concentrations. The effect is likely modest but could weaken antianginal efficacy.
How serious is the interaction between Ranolazine and Rufinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor angina frequency and increase ranolazine dose within the labeled maximum if response is reduced.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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