Drug interactions
Ranolazine + Selpercatinib
Severity: Moderate
Ranolazine and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval and ranolazine also has dose-related QT effects. The combination may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Ranolazine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Selpercatinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG and electrolytes at baseline and periodically during treatment. Correct hypokalemia and hypomagnesemia, and reduce or withhold doses if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Ranolazine with Selpercatinib?
MediHelp rates the interaction as moderate. Ranolazine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval and ranolazine also has dose-related QT effects. The combination may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Ranolazine and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically during treatment. Correct hypokalemia and hypomagnesemia, and reduce or withhold doses if QTc becomes markedly prolonged.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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