Drug interactions
Ranolazine + Sorafenib
Severity: Moderate
Ranolazine and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so combined use may raise the risk of torsades de pointes. The risk increases with electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Ranolazine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and monitor QTc periodically during therapy. Correct potassium, magnesium and calcium before and during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Ranolazine with Sorafenib?
MediHelp rates the interaction as moderate. Ranolazine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QTc interval, so combined use may raise the risk of torsades de pointes. The risk increases with electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Ranolazine and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc periodically during therapy. Correct potassium, magnesium and calcium before and during treatment.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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