Drug interactions
Ranolazine + Sotorasib
Severity: Moderate
Ranolazine and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a CYP3A4 inducer and a P-gp inhibitor, so its net effect on ranolazine is uncertain. Induction may lower ranolazine levels and P-gp inhibition may raise them.
What this interaction means in plain words
Ranolazine and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Sotorasib belongs to Oncology.
Why it happens
Sotorasib induces CYP3A4 and inhibits P-glycoprotein, with opposing effects on ranolazine exposure.
What to do
Monitor angina control and ranolazine adverse effects, including QT and dizziness, and adjust dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Ranolazine with Sotorasib?
MediHelp rates the interaction as moderate. Ranolazine and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a CYP3A4 inducer and a P-gp inhibitor, so its net effect on ranolazine is uncertain. Induction may lower ranolazine levels and P-gp inhibition may raise them.
How serious is the interaction between Ranolazine and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor angina control and ranolazine adverse effects, including QT and dizziness, and adjust dose accordingly.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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