Drug interactions
Ranolazine + Timolol
Severity: Minor
Ranolazine and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a weak CYP2D6 inhibitor and may modestly raise timolol exposure, potentially increasing bradycardia or hypotension. The clinical effect is usually small.
What this interaction means in plain words
Ranolazine and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ranolazine belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP2D6-mediated timolol metabolism.
What to do
Monitor heart rate and blood pressure when ranolazine is added. Adjust timolol only if symptomatic bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Timolol?
MediHelp rates the interaction as minor. Ranolazine and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine is a weak CYP2D6 inhibitor and may modestly raise timolol exposure, potentially increasing bradycardia or hypotension. The clinical effect is usually small.
How serious is the interaction between Ranolazine and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when ranolazine is added. Adjust timolol only if symptomatic bradycardia or hypotension occurs.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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