Drug interactions
Ranolazine + Tolterodine
Severity: Minor
Ranolazine and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine weakly inhibits CYP2D6 and may modestly raise tolterodine exposure. The effect is expected to be small and seldom clinically important.
What this interaction means in plain words
Ranolazine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ranolazine belongs to Cardiovascular; Tolterodine belongs to Genitourinary.
Why it happens
Weak inhibition of CYP2D6 metabolism of tolterodine by ranolazine.
What to do
No dose adjustment is usually needed; watch for increased anticholinergic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Tolterodine?
MediHelp rates the interaction as minor. Ranolazine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine weakly inhibits CYP2D6 and may modestly raise tolterodine exposure. The effect is expected to be small and seldom clinically important.
How serious is the interaction between Ranolazine and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; watch for increased anticholinergic effects.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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