Drug interactions
Ranolazine + Vandetanib
Severity: Major
Ranolazine and Vandetanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib causes marked, dose-related QT prolongation and torsades de pointes, and ranolazine adds further QT prolongation. Combined use can produce life-threatening arrhythmia.
What this interaction means in plain words
Ranolazine and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ranolazine belongs to Cardiovascular; Vandetanib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization by both drugs.
What to do
Avoid the combination; vandetanib labeling advises against QT-prolonging drugs. If unavoidable, do frequent ECG monitoring and keep potassium, magnesium and calcium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Ranolazine with Vandetanib?
MediHelp rates the interaction as major. Ranolazine and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vandetanib causes marked, dose-related QT prolongation and torsades de pointes, and ranolazine adds further QT prolongation. Combined use can produce life-threatening arrhythmia.
How serious is the interaction between Ranolazine and Vandetanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; vandetanib labeling advises against QT-prolonging drugs. If unavoidable, do frequent ECG monitoring and keep potassium, magnesium and calcium normal.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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