Drug interactions
Rasagiline + Rizatriptan
Severity: Major
Rasagiline and Rizatriptan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rizatriptan is metabolized mainly by MAO-A, so MAO inhibition can raise its levels, and both agents add serotonergic activity. Rizatriptan labeling contraindicates MAO-A inhibitors; rasagiline is MAO-B selective but loses selectivity at higher doses.
What this interaction means in plain words
Rasagiline and Rizatriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rasagiline belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
MAO inhibition may reduce rizatriptan metabolism, with additive serotonergic effects.
What to do
Avoid the combination where possible, or use a lower rizatriptan dose with monitoring for serotonin toxicity and hypertension. Consider a triptan not cleared by MAO or another migraine therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Rasagiline with Rizatriptan?
MediHelp rates the interaction as major. Rasagiline and Rizatriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rizatriptan is metabolized mainly by MAO-A, so MAO inhibition can raise its levels, and both agents add serotonergic activity. Rizatriptan labeling contraindicates MAO-A inhibitors; rasagiline is MAO-B selective but loses selectivity at higher doses.
How serious is the interaction between Rasagiline and Rizatriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use a lower rizatriptan dose with monitoring for serotonin toxicity and hypertension. Consider a triptan not cleared by MAO or another migraine therapy.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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