Drug interactions
Rasagiline + Sevoflurane
Severity: Moderate
Rasagiline and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can alter hemodynamic responses to general anesthesia. Evidence for rasagiline with sevoflurane is limited.
What this interaction means in plain words
Rasagiline and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rasagiline belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Pharmacodynamic interaction through altered catecholamine handling; mechanism not well established.
What to do
Inform the anesthesia team and monitor hemodynamics closely. Avoid indirect sympathomimetics and meperidine perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Rasagiline with Sevoflurane?
MediHelp rates the interaction as moderate. Rasagiline and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can alter hemodynamic responses to general anesthesia. Evidence for rasagiline with sevoflurane is limited.
How serious is the interaction between Rasagiline and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and monitor hemodynamics closely. Avoid indirect sympathomimetics and meperidine perioperatively.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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