Drug interactions
Rasagiline + Stiripentol
Severity: Moderate
Rasagiline and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can both inhibit and induce CYP1A2, so rasagiline exposure may rise or fall unpredictably. This can lead to toxicity or loss of efficacy.
What this interaction means in plain words
Rasagiline and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rasagiline belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Variable modulation of CYP1A2-mediated rasagiline metabolism.
What to do
Monitor clinical response and adverse effects after starting or stopping stiripentol. Adjust the rasagiline dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Rasagiline with Stiripentol?
MediHelp rates the interaction as moderate. Rasagiline and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can both inhibit and induce CYP1A2, so rasagiline exposure may rise or fall unpredictably. This can lead to toxicity or loss of efficacy.
How serious is the interaction between Rasagiline and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adverse effects after starting or stopping stiripentol. Adjust the rasagiline dose as needed.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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